Phd Doctoral Position In New Delivery Strategies For The Treatment Of Paediatric Rare Diseases

Organisation/Company Montenegro Research Group – CIQUS Research Field Chemistry Biochemistry Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 31 Oct *********:59 (Europe/Madrid) Country Spain Type of Contract Temporary Job Status Full-time Hours Per Week 37 Offer Starting Date 1 Feb **** Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The research groups led by Dr Javier Montenegro García at the Universidade de Santiago de Compostela (USC) and Dr Ma Luz Couce Pico at the Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) seek a doctoral candidate for a joint PhD project. The research will focus on the design and evaluation of non-viral vectors and strategies for delivering nucleic acids and proteins for therapeutic applications in paediatric rare diseases.
The candidate will participate in the design of new non-viral vectors and nanoparticle formulations for the delivery of nucleic acids, such as messenger RNA (mRNA) and plasmid DNA, and/or modified proteins for the treatment of paediatric rare diseases (e.g., lysosomal storage diseases). The candidate will be trained in a top-level research environment as part of a multidisciplinary scientific project involving two excellent research groups. The candidate will gain experience in a range of experimental techniques at the interface between chemistry, pharmacy and medicine, including electrophoresis; RNA production (PCR, plasmid purification); in vitro/ex vivo mRNA delivery studies in cells, including primary patient cells; animal biodistribution studies using IVIS; in vivo studies of nanoparticle efficacy and toxicity in an animal model of a rare disease; scientific writing, group meetings and dissemination activities.
Requirements
Research Field Biological sciences Education Level Master Degree or equivalent
Skills/Qualifications
A degree and a Master's degree (or equivalent) in Biology, Pharmacy, Biochemistry, Biotechnology, Chemistry or a related discipline are required. Academic record and CV, experience in in vitro studies (cell culture, cytotoxicity or permeability), interest in or experience with in vivo animal models, and English at B2 level or higher will be valued.
Specific Requirements
Candidates must meet the requirements for admission to a doctoral programme in the corresponding academic year and must not have previously held a predoctoral contract for the same purpose. Candidates who obtain at least 50 points in the merit assessment will be interviewed.
Work Location(s)
Number of offers available 1 Company/Institute University of Santiago de Compostela (USC) – CiQUS Country Spain State/Province LA CORUÑA City SANTIAGO DE COMPOSTELA Postal Code ***** Street Rúa Jenaro de la fuente s/n Geofield
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